Published Literature
Peer Reviewed Scientific Studies

Peer-Reviewed Scientific Publications On High-Energy Extracorporeal Shock Wave for Musculoskeletal Conditions

* Articles with an asterisk indicate a use that has not been approved or cleared by the U.S. Food and Drug Administration. PulseVet is providing this information in an educational format and to provide a complete listing of high energy ESWT articles and makes no claims as to the effectiveness of OssaTron® treatments, other than those approved by the FDA.

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Basic Science: Studies
  • Gutersohn A, Caspari G, and Erbel R. Upregulation of VEGF-mRNA in human umbilical vascular endothelial cells via shock waves. Presentation; Eur J Heart Failure 2000;2(Suppl1):42. 

Human umbilical vascular endothelial cells were placed into the focus of shock waves at energy flux densities of 0.05, 0.1 and 0.3 mJ/mm2 (“modified lithotripter”). After shock wave treatment cells were grown for 24-36h, and tested for VEGF-mRNA. Esw treated cells revealed a significant increase of VEGF-mRNA versus controls. Cell death increased with increasing esw energy levels.

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Pre Clinical Studies
  • Haupt G, and Chvapil M. Effect of shock waves on the healing of partial-thickness wounds in piglets. J Surg Res 1990;49:45-48. 
  • Re-epithelialization of wounds inflicted in normal or previously irradiated skin of piglets was significantly enhanced by low energy shock-wave treatment (Experimental Lithotripter XL1, Dornier, 1000 pulses at 14 or 18 kV energy level). Shock waves of intermediate (or high) energy were without effect. 
  • Kamelger FS, Djedovic G, Meirer R, and Piza-Katzer H. Deep partial thickness burn injury and the effect of eswt. An experimental investigation in rats. Presentation no. 65; 8th Int Congress of the ISMST, May 29th to June 1st 2005, Vienna, Austria. 
  • Standardized deep partial thickness burns were applied to the backs of 30 rats. Immediately after burns the esw treatment (0.11 mJ/mm2, 500 pulses) was applied on selected areas, whereas the remainder of the burns served as untreated controls. Re-epithelization was improved significantly at days 5 and 15, wound closure over time was enhanced as well (both, p < 0.05). 
  • Meirer R, Kamelger FS, Huemer GM, Wanner S, and Piza-Katzer H. Extracorporeal shock wave may enhance skin flap survival in an animal model. Presentation no. 59; 8th Int Congress of the ISMST, May 29th to June 1st 2005, Vienna, Austria. 
  • Meirer R, Kamelger FS, Huemer GM, Wanner S, and Piza-Katzer H. Extracorporeal shock wave may enhance skin flap survival in an animal model. Br J Plast Surg. 2005;58(1):53-57.
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